Ipamorelin
Ipamorelin (Selective GHRP-5)
Selective Growth Hormone Releasing Peptide for Strength
What is Ipamorelin?
Ipamorelin is a selective growth hormone releasing peptide (GHRP) that stimulates the pituitary gland to produce and release growth hormone (GH). It is a pentapeptide (five amino acids) that acts as a ghrelin/growth hormone secretagogue receptor agonist, triggering the natural pulsatile release of growth hormone.
What makes ipamorelin unique among growth hormone releasing peptides is its selectivity. Unlike other GHRPs such as GHRP-6 or GHRP-2, ipamorelin does not significantly increase cortisol, prolactin, or appetite. This selectivity makes it one of the safest and most well-tolerated growth hormone peptides available.
Ipamorelin promotes lean muscle growth, enhances fat metabolism, improves recovery from exercise and injury, strengthens bones, and supports better sleep quality. It works synergistically with growth hormone releasing hormones (GHRH) like CJC-1295, and the two are often used together for enhanced results.
The growth hormone release from ipamorelin follows a natural pulsatile pattern, which helps maintain the body's normal hormonal feedback mechanisms and reduces the risk of desensitization that can occur with continuous GH stimulation.
Research Supply
Source high-purity Ipamorelin for your research
Dosage Guide
Route: Subcutaneous injection, 2-3 times daily
Dosing Schedule
| Period | Dose |
|---|---|
| Standard | 200-300 mcg per injection, 2-3 times daily |
| Beginner | 100-200 mcg per injection, 2 times daily |
| Advanced | 300 mcg per injection, 3 times daily |
Reconstitution
Injection Volumes
| Dose | Volume | Syringe Units |
|---|---|---|
| 100 mcg | 0.04 mL | 4 units |
| 200 mcg | 0.08 mL | 8 units |
| 250 mcg | 0.1 mL | 10 units |
| 300 mcg | 0.12 mL | 12 units |
Cycling Protocol
8-12 weeks
4 weeks
Cycle to prevent receptor desensitization. Repeat as needed.
Administration Tips
- Inject subcutaneously in the abdomen, thigh, or upper arm
- Do not eat for at least 30 minutes before and after injection (food, especially carbs and fats, can blunt GH release)
- Rotate injection sites
- Store reconstituted solution refrigerated and use within 28 days
- Optimal timing: morning upon waking, post-workout, and 30-60 minutes before sleep
Risks & Side Effects
Commonly Reported
Serious Risks
Carpal tunnel syndrome
From elevated GH levels; usually dose-dependent.
Joint pain
Particularly at higher doses.
Insulin resistance
With prolonged high-dose use.
Allergic reactions
Rare; discontinue if swelling or difficulty breathing occurs.
Contraindications
- Active cancer or history of cancer
- Known hypersensitivity to ipamorelin
- Pregnancy or breastfeeding
- Diabetic retinopathy
- Children and adolescents (unless under medical supervision for growth deficiency)
Frequently Asked Questions
Related Peptides
Experts Covering Ipamorelin
Dr. William A. Seeds
MD -- Regenerative Medicine Pioneer
Dr. Andrew Huberman
PhD -- Stanford Neuroscientist
Jay Campbell
Health Optimization Author and Peptide Advocate
Dr. Ian W. Hamley
Diamond Professor of Physical Chemistry -- University of Reading
Matthew Farrahi
Biohacker, CEO of Sigma Compounds, and Fitness Creator
LEGAL DISCLAIMER
The information provided on this page is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any peptide therapy. Individual results may vary. Peptides Institute is not responsible for any adverse effects resulting from the use of information provided on this site.