TB-500
TB-500 (Thymosin Beta-4 Synthetic)
Thymosin Beta-4 Analog for Healing and Recovery
What is TB-500?
TB-500 is a synthetic version of Thymosin Beta-4 (TB4), a naturally occurring 43-amino acid peptide present in virtually all human and animal cells. Thymosin Beta-4 is one of the most abundant intracellular peptides and plays a central role in the protection, regeneration, and remodeling of injured or damaged tissues.
TB-500 promotes healing through several key mechanisms: upregulation of actin (a cell-building protein essential for tissue repair), promotion of cell migration to injury sites, reduction of inflammation, stimulation of new blood vessel growth (angiogenesis), and regulation of wound healing processes. Its ability to promote cell migration is particularly significant, as it allows repair cells to travel through damaged tissue more efficiently.
TB-500 has shown efficacy in healing a wide range of injuries including muscle tears, tendon injuries, ligament sprains, skin wounds, and even cardiac tissue damage. It has been extensively used in veterinary medicine, particularly in equine sports medicine, for decades before gaining popularity in human biohacking and sports recovery communities.
TB-500 is often used in combination with BPC-157 for enhanced healing effects, as the two peptides work through complementary mechanisms.
Research Supply
Source high-purity TB-500 for your research
Dosage Guide
Route: Subcutaneous or intramuscular injection
Dosing Schedule
| Period | Dose |
|---|---|
| Loading phase | 2-2.5 mg twice weekly for 4-6 weeks |
| Maintenance | 2 mg once weekly for 4-6 weeks |
| Injury protocol | 2.5 mg twice weekly until healed |
Reconstitution
Injection Volumes
| Dose | Volume | Syringe Units |
|---|---|---|
| 2.0 mg | 0.8 mL | 80 units |
| 2.5 mg | 1.0 mL | 100 units |
Cycling Protocol
4-6 weeks loading + 4-6 weeks maintenance
2-4 weeks
Often stacked with BPC-157 for synergistic healing effects.
Administration Tips
- TB-500 is systemically active, so injection site does not need to be near the injury
- Subcutaneous injection in the abdomen is the most common method
- Intramuscular injection near the injury site is also effective
- Rotate injection sites
- Store reconstituted solution refrigerated and use within 28 days
Risks & Side Effects
Commonly Reported
Serious Risks
Allergic reactions
Swelling, rash, or difficulty breathing; discontinue immediately.
Theoretical cancer concern
TB-500 promotes angiogenesis and cell migration, which could theoretically support tumor growth in individuals with existing cancer. No direct evidence supports this concern, but caution is warranted.
Cardiovascular effects
Thymosin Beta-4 has been found in cardiac tissue and may affect heart function at very high doses.
Contraindications
- Active cancer or history of cancer (precautionary due to cell proliferation and angiogenic properties)
- Known hypersensitivity to TB-500 or Thymosin Beta-4
- Pregnancy or breastfeeding
- Acute cardiac events (recent heart attack or stroke)
Frequently Asked Questions
Related Peptides
Experts Covering TB-500
Dr. William A. Seeds
MD -- Regenerative Medicine Pioneer
Dr. Andrew Huberman
PhD -- Stanford Neuroscientist
Jay Campbell
Health Optimization Author and Peptide Advocate
Dr. Ian W. Hamley
Diamond Professor of Physical Chemistry -- University of Reading
Matthew Farrahi
Biohacker, CEO of Sigma Compounds, and Fitness Creator
LEGAL DISCLAIMER
The information provided on this page is for educational and informational purposes only and is not intended as medical advice. TB-500 has not been approved by the FDA for any medical condition. Always consult with a qualified healthcare professional before starting any peptide therapy. Individual results may vary. Peptides Institute is not responsible for any adverse effects resulting from the use of information provided on this site.